Improvement in CVI related signs...
Conservative therapy of chronic venous insufficiency
(CVI) consists largely of compression treatment. However, this often causes
discomfort and has been associated with poor compliance. Therefore, oral drug
treatment is an attractive alternative.
The objectives of this trial were to review the evidence
from rigorous clinical trials assessing the efficacy and safety of oral horse
chestnut seed extract (HCSE) versus placebo, or other treatments for CVI.
Overall, there appeared to be an improvement in CVI related
signs and symptoms with HCSE compared with placebo. Leg pain was assessed in
seven placebo-controlled trials. The evidence presented implies that HCSE is
an efficacious and safe short-term treatment for CVI.
However, several caveats exist and more rigorous RCTs
are required to assess the efficacy of this treatment option.
Cochrane Database Syst Rev. 2004;2:CD003230
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