Quest Vitamins LTD,
Molybdenum occurs as a cofactor bound to major enzymes involved in metabolism.
Molybdenum is necessary for the functioning of the enzyme xanthine oxidase that is involved in Iron metabolism and also in the production of uric acid (a waste product found in the blood and urine). Molybdenum is also needed for normal sexual functioning in the male.
Deficiency of molybdenum results in inadequate uric acid production and may affect the reproductive capacity of males. Molybdenum deficiency may also increase susceptibility to Dental Caries.
Upper safe level for daily supplementation = 200?g
There is no EC Recommended Daily Allowance for molybdenum. The 1991 COMA panel on Dietary Reference Values believed safe intakes were between 50 and 400?g per day for adults.
Except in proven molybdenum deficiency, there are no known therapeutic uses of supplemental molybdenum except perhaps to detoxify excess Copper. However, preliminary research does suggest that molybdenum may be helpful for reducing the risk of sulfite-reactive Asthma attacks (1). Molybdenum may be included in a general multivitamin and mineral supplement to ensure a sufficiency of this mineral.
Excessive molybdenum intakes (10-15 mg per day) may be associated with altered uric acid metabolism and with impaired Copper bioavailability. Such a dosage is extremely difficult to achieve with normal dietary and supplementation practices.
There are no known drug interactions or contra-indications for molybdenum.
Molybdenum is fairly widespread in foods, with no one category of food being particularly richer in this mineral than another.
1. Johnson JL et al. Molybdenum cofactor deficiency in a patient previously characterised as deficient in sulfite oxidase. Biochem Med Metabol Biol 1988;40:86-93.